Cristina Pujades Corbi

PhD, Principal Investigator
Associate Professor (Professor Titular)
Department of Experimental and Health Sciences

Universitat Pompeu Fabra
PRBB, Dr Aiguader 88
08003 Barcelona, Spain


Biography note

Academic degrees:

  • 1986            Licenciatura en Biología, University of Barcelona 
  • 1991            PhD in Biology, University of Barcelona

Research Experience:   

  • 1987-91        PhD student, Universitat de Barcelona
  • 1991-95        Postdoctoral fellow, DFCI-Harvard Medical School, Boston
  • 1995-99        Postdoctoral fellow, Ecole Normale Supérieure, Paris
  • 1999-2007     Maître de Conférences, Université Pierre et Marie Curie, Paris
  • 2002-06        Ramón y Cajal Researcher, Universitat Pompeu Fabra, Barcelona
  • From 2007      Profesor Titular, Universitat Pompeu Fabra, Barcelona   

Awards and fellowships:

  • 2007            I3 award for the intensification of the research activity, UPF
  • 1997-99       Postdoctoral fellowship of Tranining and Mobility of Researchers from EU (Marie-Curie fellowship)
  • 1995-97       Postdoctoral longterm fellowship from Human Frontiers Science Program
  • 1994            Post-doctoral fellowship from Lady Tata Trust (UK)
  • 1991-93       Postdoctoral long term fellowship from Ministerio de Educación y Ciencia (Spain) 

Research lines

We are interested in understanding how sensory inputs from the inner ear are conveyed and relayed into the hindbrain, and how neural circuits are then established within the brain. Our approach has been to dissect how neural elements of both structures are generated upon morphogenesis, in order to undarstand how they can connect later on. We use zebrafish embryos because they allow us to combine genetic tools with high resolution imaging techniques. We think this approach will provide us understanding in different biological processes such as patterning and morphogenesis, andreveal principles underlying how the circuits in the brain produce behavior. 


  • Graduate studies

Biología del Desarrollo, 2nd year Biología Humana, UPF (lecturer)
Biología Molecular y Celular 3, 1 st year Ingeniería Biomédica, UPF (coordinator and lecturer)

  • Postgraduate studies
Model Organisms in Biomedical Research, Master in Biomedical Research, DCEXS-UPF (coordinator and lecturer) 
Neural Development, Master in Neurosciences, UB (invited lecturer) 
Advanced Techniques in Genetic Engineering, Master in Genetics and Developmental Biology, UB (invited lecturer)
Experimental Models in Translational Genetics, Master in Translational Medicine, UB (invited lecturer)
Embryology, Master in Genetic Counseling, IDEC (invited lecturer)



Kamaid A, Molina-Villa T, Mendoza V, Pujades C, Maldonado E, Ispizua Belmonte JC, López-Casillas F. Betaglycan knock-down causes embryonic angiogenesis defects in zebrafish. Genesis Jul 15; 2015

Terriente, J, Pujades, C. Cell segregation in the hindbrain: do boundaries matter?. Invited review. Cell Mol Life Sci, DOI: 10.1007/s00018-015-1953-8, 2015

Zecca, A, Dyballa, S, Voltes, A, Bradley, R, Pujades, C. The order and place of neuronal differentiation establish the topography of sensory projections and the entry points within the hindbrain, J Neuroscience 35(19):7475-86. doi: 10.1523/JNEUROSCI.3743-14, 2015

Joya, X, Garcia-Algar, O, Vall, O, Pujades, C. Transient exposure to ethanol during zebrafish embryogenesis results in defects in neuronal differentiation: an alternative model system to study FASD. PLoS ONE 9(11):e112851. doi: 10.1371/journal.pone.0112851, 2014 

Joya, X, Garcia-Algar, O, Salat-Batlle, J Pujades, C, Vall, O. Advances in the development of novel antioxidant therapies as an approach for fetal alcohol syndrome prevention. Birth Defects Res A Clin Mol Teratol Aug 18. doi: 10.1002/bdra.23290. [Epub ahead of print], 2014 

Calzolari*, S, Terriente*, J, Pujades, C. Cell segregation in the rhombomeric boundaries relies in physical mechanisms based in an actomyosin cable. EMBO J Apr 1;33(7):686-701, 2014

Vendrell, V, Vázquez-Echeverría, C, López-Hernández, I, Durán, B, Alonso, MT, Martinez, S, Pujades, C, Schimmang, T. Roles of Wnt8a during formation and patterning of the murine inner ear. Mech Dev, Oct 4. doi: 10.1016/j.mod.2012.09.009 [Epub ahead of print], 2013 

Terriente, J, Pujades, C. The use of zebrafish embryos for small molecule screening related to cancer. Dev. Dyn., Dec 3. doi: 10.1002/dvdy.23912 [Epub ahead of print], 2012

Sapède*, D, Dyballa*, S, Pujades, C. Cell lineage analysis reveals three different progenitor pools for neurosensory elements in the otic vesicle. J Neurosc, 32(46):16424-16434,2012

Coll-Lladó, M, Acinas, S.G., Pujades, C, Pedrós-Alió, C. Transcriptome fingerprinting analysis: an approach to explore gene expression patterns in marine microbial communities. PLoS ONE 6(8): e22950, 2011

C Miró-Julià, S Roselló, VG Martínez, DR Fink, C Escoda-Ferran, O Padilla, C Vázquez-Echeverría, P Espinal-Marin, C Pujades, A García-Pardo, J Vila, C Serra-Pagès, U Holmskov, J Yélamos, F Lozano. Molecular and functional characterization of mouse s5d-srcrb, a new member of the group b scavenger receptor cysteine-rich superfamily. J Immunol 186(4): 2344-54, 2011

Jimenez-Guri, E, Pujades, C An ancient mechanism of hindbrain patterning has been conserved in vertebrate evolution. Evol Dev, 13:1, 38–46, 2011

Jimenez-Guri, E, Udina, F, Colas, JF, Sharpe, J, Padrón, L, Torres M, Pujades, C. Clonal analysis in mice underlines the importance of positional information during hindbrain segmentation. PLoS ONE 5(4): e10112, 2010

Sapède, D., Pujades, C. Hedgehog signaling governs the development of sensory epithelium and its associated innervation in the zebrafish inner ear, J Neurosc 30: 3612-3623, 2010

Aragón, F., Pujades, C. FGF signaling controls caudal hindbrain specification through Ras-ERK1/2 pathway, BMC Dev Biol, 9:61, 2009 

Alsina, B., Giraldez, F. and Pujades, C. Patterning and cell fate in inner ear development. Review in Science in Hispania Special Issue, Int J Dev Biol, 53(8-10):1503-13, 2009 

Vázquez-Echeverría, C., Dominguez-Frutos, E., Charnay, P., Schimmang, T., Pujades, C. Analysis of kreisler mutants reveals new roles of the hindbrain-derived signals in the establishment of the otic neurogenic domain. Dev Biol, 322(1):167-78,2008

Schneider-Maunoury, S, Pujades, C..  Hindbrain signals in otic regionalization: walk on the wild side. Invited Review in Ear Development Special Issue, Ed F Giraldez and B Fritzsch, Int J Dev Biol 51(6-7):495-506, 2007

Guimarães, E. Domínguez del Toro, F. Chatonnet, L. Wrobel, C. Pujades, L. S. Monteiro, J. Champagnat. Exposure to Retinoic Acid at the Onset of Hindbrain Segmentation Induces Episodic Breathing in Mice. Eur J Neurosc 25, 1-11, 2007 

Lecaudey, V., Ulloa, E., Anselme, I., Stedman, A. Schneider-Maunoury, S., Pujades, C. Role of the hindbrain in patterning the otic vesicle: a study of the zebrafish vhnf1 mutant. Dev Biol 303, 134-143, 2007

Pujades, C, Kamaid, A, Alsina, B, Giraldez, F. BMP4 regulates the development of hair cells by modulating progenitor cell survival. Dev Biol, Apr 1;292(1):55-67, 2006

Aragón, F., Vazquez-Echeverría, C., Ulloa, E., Reber, M., Cereghini, S., Alsina, B., Giraldez, F., Pujades, C. vHnf1 regulates specification of caudal rhombomere identity in the chick hindbrain. Dev Dyn 234(3), pp. 567-76, 2005

B. Alsina, G. Abello, E. Ulloa, D. Henrique, C. Pujades, F. Giraldez. FGF10 is required for epithelial differentiation of otic neuroblasts. Dev Biol 267:119-134, 2004

F. Mechta, F. Giudicelli, C. Pujades, P. Charnay, M. Yaniv. kreisler control c-jun regulation and function in the developing hindbrain. Dev Biol 258: 419-431, 2003

C. Pujades *, B. Guez-Guez, D. Dunon. MCAM, a cell adhesion molecule expressed in the myogenic lineage during early chick embryonic development. Int J Dev Biol 46: 263-266, 2002              * corresponding author


O. Voiculescu, E. Taillebourg, C. Pujades, C. Kress, S. Buart, P. Charnay, S. Scheneider-Maunoury. Hindbrain patterning: Krox20 couples segmentation and specification of regional identity. Development 128: 4967-4978, 2001


S. Allais, N. Allioli, C. Pujades, O. Vanio, B. Imhoff, D. Dunon. HEMCAM regulates cell surface expression of ß1 integrins. J Cell Sci 114: 1847-1859, 2001


F. Helmbacher, C. Pujades, C. Desmarquet, M. Frain, F. Rijli, P. Chambon, P. Charnay. Hoxa-1 and Krox-20 synergize in the patterning of rhombomere 3. Development 125: 4739-4748, 1998


C. Pujades , R. Allon, R. Yaucht, L. Burkly, T. Springer, R. Lobb, M.E. Hemler. Defining extracellular integrin αchain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding.Mol Biol Cell 8, No. 12: 2647-2657, 1997


J.B. Weitzman, C. Pujades, M.E. Hemler. Integrin alpha chain cytoplasmic tails regulate "antibody-redirected" cell adhesion, independently of ligand binding. Eur J Immunol, No. 27, pp. 78-83, 1997


C. Pujades , J. Teixidó, G. Bazzoni, M.E. Hemler. Integrin α4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to α4/180 formation. Biochem J No. 313: 899-908, 1996


M.E. Hemler, C. Pujades, J. Bodorova. CD49e (VLA-5) report. Leukocyte typing V (ed. S. Schlossman et al.), Oxford University Press, Oxford, 1994


C.M. Parker, C. Pujades, M.B. Brenner, M.E. Hemler. α4/180: a novel form of the integrin α4 subunit. J Biol Chem 268, No. 10: 7028-7035, 1993


R. Bastos, P. Engel, C. Pujades, R. Falchetto, R. Aligué, O. Bachs. Increase of cytokeratin D during liver regeneration: association with the nuclear matrix. Hepatology 16, No. 6: 1434-1446, 1992


C. Pujades *, E. Forsberg, C. Enrich, S. Johansson. Changes in cell surface expression of fibronectin and fibronectin receptor α5ß1 during liver regeneration. J Cell Sci 102: 815 -820, 1992                      * corresponding author


C. Pujades , R. Bastos, C. Enrich, O. Bachs. Decrease of calmodulin and actin in the plasma membrane of rat liver cells during proliferative activation. Biochem Biophys Res Comun 173, No. 3: 1287, 1990


C. Pujades *, C. Enrich, S. Johansson. Purification of fibronectin receptor α5ß1 from rat liver cells. Generation of antibodies against it. Inmunología 9, No. 4: 133-139, October Desember 1990        * corresponding author


R. Aligué, R. Bastos, J. Serratosa, C. Enrich, P. James, C. Pujades, O. Bachs. Increase of a 55 kd keratin-like protein in the nuclear matrix of rat liver cells during proliferative activation. Exp Cell Res 186: 346-353, 1990


Centre Civic Urgell: Tastets de neurociències, 2015

PRBB Biojunior, 2015

Fira de la Recerca en Directe: Seguint el llinatge cel.lular in vivo: com podem veure la dinàmica de les cèl•lules durant el seu desenvolupament embrionari?, 2015

Centre Cívic Urgell: Receptes i plànols per fer un cervell, 2015

El problema de Gettier, La Xarxa 2014

Desarrollo y evolución del rombencéfalo: una historia compartida, Mente y Cerebro, 2014

The making of the vertebrate brain: a soap-opera?, Omniscellula 2012

Interview in the Project Fem talent, 2011

Organismes model en Biologia, Treballs de la Societat Catalana de Biologia, Vol 62, 2011

Grid-Spinoza project : Exploración sobre los procesos de creación (artística y científica), (Hangar-PRBB collaboration), 2010

Fête de la Science, Institut Français, Barcelone: L’infiniment petit, 2010

Scientific coffee: El ratolí, la mosca I l’home. Casa Orlandai, 2010

Collaborator in Escolab 2010, ICUB (Institut de Cultura de Barcelona)

Invited seminar: Desenvolupament del SNC: receptes i plànols per fer un cervell, Brain Awareness Week 2010

Invited speaker in the Observatori Fabra within the framework Nits amb estrelles, Barcelona 2009 

Author of a child book within the collection Tu també pots ser investigador: Receptes i plànols per fer un organisme

Collaborator in Vine al labo 2007, Societat Catalana de Biologia

Invited speaker in the summer course of the Universitat Pompeu Fabra Gènere i ciencia. Barcelona 2007

Workshop in Embriology: El cervell en directe, Brain Awareness Week, Brain Awareness Week 2006

Editor of issue 26 of Transversal (Ajuntament de Lleida). Dues mirades: art i ciència, june 2005 

Invited speaker in the course El lenguaje raptado, Universidad Internacional Menéndez y Pelayo, Cuenca 2004

Collaborator in the Fira Viu la Ciència Contemporànea 2003, Societat Catalana de Biologia 

Collaborator of the on-line journal Barcelona Review: l’home que va confondre la seva dona per un barret, O Sacks

Collaborator of the magazine of contemporary culture Transversal (Ajuntament de Lleida), issue 22

Collaborator of the on-line journal Percepnet

Collaborator of the journal Médicos al día (Chile)

Collaborator of the on-line journal Biomedia (Observatori de la Comunicació Científica, UPF)