Fernando Giraldez Orgaz

Full professor
Department of Experimental and Health Sciences
Parc de Recerca Biomedica de Barcelona (PRBB)
Contact :

Nota Biografica

Date of Birth, 10 th June, 1952, in Buenos  Aires, Argentina
Nationality : Spanish

Current Position.
Professor of Developmental Biology.  Dept. Ciències Experimentals i de la Salut (CEXS), Universitat Pompeu Fabra, Barcelona, at the Parc de Recerca Biomèdica de Barcelona (PRBB).

Education and research training
Studied in IEM Ramiro de Maeztu (1969), M.D. (1975) and Ph.D. (1979) Universidad de Valladolid. Post-doctoral fellow at the University of Cambridge (UK) 1979-1983.

Teaching and Academic Experience
Lecturer in 1982 and Full Professor since 1989. Graduate and post-graduate teaching in Physiology, Developmental Biology and Neurosciences. Director and Chairman of the Department of Biochemistry, Molecular Biology and Physiology 1992-1996 and CEXS-UPF 2003-2007, Vicerrector de Investigación, Universidad de Valladolid 1998-02.

Research lines and projects .
Group leader of the Develmental Biology Group, CEXS-Universitat Pompeu Fabra. Parc de Recerca Biomèdica de Barcelona (PRBB). Current work funded by Spanish MICINN
Specific areas of research: Neuroscience and Developmental Biology. Sensory development and regeneration Current projects study the properties of otic progenitors, and the initial steps in the generation of auditory neurones and sensory hair cells. Cell-communication and intrinsic factors governing cell fate decisions are studied combining genetic, molecular and embryological techniques.

Scientific results.
Published more than eighty papers and reviews in international books and journals, including Development, Developmental Biology, J. Neuroscience, PNAS, Nature and others. Invited talks and seminars in universities and research institutes including ICRF Oxford, Kings College London, Boston University School of Medicine, EMBL-Heidelberg, Cambridge University, New York University, Freiburg, Umëa University, Purdue University, EEI-Harvard, Instituto Cajal, Juan March workshops, CECS-Chile, Centro de Biología Molecular (CBM-CSIC), Centro Nacional de Biotecnología (CNB-CSIC), as well as a number of communications and talks in scientific meetings and symposia.

Other scientific activities.
Expert and panel member for ANEP and ANECA (Spain), FCT (Portugal), MEC and CSIC. Advisor and referee of FONCYT (Argentina), Welcome Foundation, National Science Foundation (USA), BBSRC UK), Human Frontier (HFSO) and other funding agencies. Referee for Nature, Development, Developmental Biology, Intl. J. Dev Biol., Mechanisms of Development, Developmental Dynamics, Journal of Neuroscience, PLoS ONE and others.

Member of PhD committees, external examiner at the Universies of Nottingham, Lisboa, and opponent at Umea University. Member of national and international scientific societies including SENC-IBRO, SfN, SEBBM-FEBS, BSDB, SDB, alumni of Clare Hall College (Cambridge). Founder member of the Spanish Society of Developmental Biology (SEBD), and the Spanish Biophysical Society (SBE).


Recent publications 

PUJADES, C., KAMAID, A., ALSINA, B.and GIRALDEZ, F. (2006) BMP4  regulates the development of hair-cells by modulating progenitor cell survival Developmental Biology 29:55-67

GIRALDEZ, F. and FRITZSCH, B. (2007) The molecular biology of ear development - "Twenty years are nothing" Ear Development Special Issue, Ed. by Giraldez & Fritzsch, Int. J. Devel. Biol. 51: 429-438

KAMAID, A. and GIRALDEZ, F. (2008)  Btg1 and Btg2 expression during early chick development. Developmental Dynamics 237:2158-2169

BELL, D., STREIT, A., GOROSPE, I., VARELA-NIETO, I., ALSINA, B. and GIRALDEZ, F. (2008). Spatial and temporal segregation of auditory and vestibular neurons in the otic placode. Developmental Biology 322:109-120

ALSINA B., GARCIA-LOMANA, VILLÀ J., & GIRÁLDEZ F. (2009). Developmental Biology and Mathematics: the rules of an embryo AMS-RSME: Selected Topics in Mathematics, Development and Cancer. Ed. by F Giraldez and MA Herrero

ABELLÓ G. , KHATRI S. , RADOSEVIC M. , SCOTTING P.J , GIRÁLDEZ F. and ALSINA B. (2010) Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling determines the neurogenic and non-neurogenic domains in the chick otic placode Developmental Biology 339 : 166-178

KAMAID*, A., NEVES*, J. and GIRALDEZ, F. (2010) Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between BMP signaling and Atoh1. J.Neuroscience 30(34):11426-34

DOMINGUEZ, E., LOPEZ, I., VENDRELL, V., NEVES, J., GALLOZZI, M., GUTSCHE, K., QUINTANA, L., SHARPE, J., KNOEPFLER, P., EISENMAN, R., TRUMPP, A., GIRALDEZ, F. and SCHIMMANG, T. (2011) "N-myc controls proliferation, morphogenesis and patterning of the inner ear " J. Neuroscience 11;31(19):7178-89.

NEVES, J., PARADA, C., CHAMIZO, M. and GIRALDEZ, F. (2011) Jagged1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification. Development 138: 735-744

NEVES, J., UCHIKAWA, M., BIGAS, A. and GIRALDEZ, F. (2012) The Prosensory Function of Sox2 in the Chicken Inner Ear Relies on the Direct Regulation of Atoh1. PLoSONE 7(1): 1-11 News and Views, F1000, 04 May 2012.

DURAN, B., FEIJOO, A., CONDE, M., CARNICERO, E., SANCHEZ, A., GARCIA-SANCHO, J., RIVOLTA, M.N., GIRALDEZ, F. and SCHIMMANG, T. (2012) Generation of Inner Ear Sensory Cells from Bone-Marrow derived Human Mesenchymal Stem Cells. Regenerative Medicine 7(6): 1-15

NEVES, J., VACHKOV, I., and GIRALDEZ, F (2013) Sox2 regulation of hair cell development: incoherence makes sense. Special Issue Inner "Ear Development and Regeneration". Ed by Stefan Heller. Hearing Research Nov. 12, S0378-5955(12)00255-9

NEVES, J., ABELLÓ, G., PETROVIC, J. and GIRALDEZ, F. (2013)Patterning and cell fate in the inner ear:  a case for Notch in the chicken embryo. Ed by R. Ladher and T. Suzuki    Development Growth & Differentiation, 55(1):96-112.