Relevant publications


Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells. Pauls E, Ruiz A, Badia R, Permanyer M, Gubern A, Riveira-Muñoz E, Torres-Torronteras J, ALvarez M, Mothe B, Brancer C, Crespo M, Menéndez-Arias, Clotet B, Keppler OT, Posas F, Ballana E Esté JA. J Immunol 2014 Aug 15;193(4):1988-97

Control of Cdc28 CDK1 by stress-induced LncRNA. Nadal-Ribelles M, Solé C, Xu Z, Steinmetz LM, de Nadal E, Posas F. Mol Cell 2014 Feb 20;53(4): 546-61.

Dealing with transcriptional outburst during S phase to protect genomic integrity. Duch A, de Nadal E, Posas F. J Mol Biol. 2013 Nov 29;425(23):4745-55.

Initiation of the transcriptional response to hyperosmotic shock correlates with the potential for volume recovery. Geijer C, Medrala-Klein D, Petelenz-Kurdziel E, Ericsson A, Smedh M, Andersson M, Goksör M, Nadal-Ribelles M, Posas F, Krantz M, Nordlander B, Hohmann S. FEBS J. 2013 Aug 280(16):3854-67.

The Hog1 Stress-activated Protein Kinase Targets Nucleoporins to Control mRNA Export upon Stress. Regot S, de Nadal E, Rodríguez-Navarro S, González-Novo A, Pérez-Fernandez J, Gadal O, Seisenbacher G, Ammerer G, Posas F. J Biol Chem. 2013 Jun 14;288(24):17384-98.


Coordinated control of replication and transcription by a SAPK protects genomic integrity. Duch A, Felipe-Abrio I, Barroso S, Yaakov G, García-Rubio M, Aguilera A, de Nadal E and Posas F. Nature. 2013 Jan 3;493(7430):116-9.

Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling. Nadal-Ribelles M, Conde N, Flores O, Gonzalez-Vallinas J, Eyras E, Orozco M, de Nadal E and Posas F.  Genome Biol. 2012 Nov 18;13(11):R106.

Response to hyperosmotic stress. Saito H, Posas F.  Genetics. 2012 Oct;192(2):289-318.

The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Ruiz-Roig C, Noriega N, Duch A, Posas F and de Nadal E. Mol Biol Cell, 2012 Sep 5.

A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress. Joaquin M, Gubern A and Posas F.  Cell Cycle, 2012 Aug 23;11(18).

The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses.  Duch A, de Nadal and Posas F.  FEBS Lett. 2012 Aug 31;586(18):2925-31. Epub 2012 Jul 20.

The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. Joaquin M, Gubern A, González-Nuñez D, Josué Ruiz E, Ferreiro I, de Nadal E, Nebreda AR and Posas F. EMBO J. 2012 May 8. doi: 10.1038/emboj.2012.122. 

Distributed computation: the new wave of synthetic biology devices. Macía J, Posas F, Solé R. Trends Biotechnol. 2012 Apr 17.

Sic1 plays a role in timing and oscillatory behaviour of B-type cyclins. Barberis M, Linke C, Adrover MA, González-Novo A, Lehrach H, Krobitsch S, Posas F and Klipp E. Biotechnol Adv. 2012 Jan;30(1):108-30. Epub 2011 Sep 18.

Sir2 plays a key role in cell fate determination upon SAPK activation. Vendrell A and Posas F. Aging, 2011, 3 (12): 1163-8

Controlling gene expression in response to stress. de Nadal E, Ammerer G, and Posas F.  Nat Rev Genet. 2011 Nov 3. doi: 10.1038/nrg3055. 

Elongating under stress. de Nadal and Posas F. Genetics Research International. Volume 2011 (2011), Article ID 326286

Time-Dependent Quantitative Multicomponent Control of the G1-S Network by the Stress-Activated Protein Kinase Hog1 upon Osmostress. Adrover MA, Zi Z, Duch A, Schaber J, González-Novo A, Jimenez J, Nadal-Ribelles M, Clotet J, Klipp E and Posas F. Sci Signal. 2011 Sep 27;4(192):ra63.

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M and  Posas F. EMBO Rep. 2011 Aug 12. doi: 10.1038/embor.2011.154.

Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress. Solé C, Nadal-Ribelles M, Kraft C, Peter M, Posas F and de Nadal E. EMBO J. 2011 Jul 8;30(16):3274-84 

Design, Synthesis and Characterization of a Highly Effective Inhibitor for Analog-Sensitive (as) Kinases. Klein M, Morillas M, Vendrell A, Brive L, Gebbia M, Wallace IM, Giaever G, Nislow C, Posas F and Grøtli M. PLoS One. 2011;6(6):e20789. Epub 2011 Jun 17.

Transient activation of the HOG MAPK pathway regulates bimodal gene expression. Pelet S, Rudolf F, Nadal-Ribelles, de Nadal, Posas F and Peter M. Science. 2011 May 6;332(6030):732-5. 

Distributed biological computation with multicellular engineered networks. Regot S, Macia J, Conde N, Furukawa K, Kjellén T, Peeters T, Hohmann S, de Nadal, Posas F and Solé R. Nature. 2011 Jan 13;469(7329):207-11


The p38 SAPK is recruited to chromatin via its interaction with transcription factors. Ferreiro I, Barragan M, Gubern A, Ballestar E, Joaquin M and Posas F. J Biol Chem. 2010 Oct 8;285(41):31819-28.

The HOG Pathway Dictates the Short-term Translational Response after Hyperosmotic Shock. Warringer J, Hult M, Regot S, Posas F and Sunnerhagen P. Mol Biol Cell. 2010 Sep 1;21(17):3080-92.

Biophysical properties of Saccharomyces cerevisae and their relationship with HOG pathway activation. Schaber J, Adrover MA, Eriksson E, Pelet S, Petelenz-Kurdziel E, Klein D, Posas F, Goksör M, Peter M, Hohmann S and Klipp E. Eur Biophys J. 2010 Oct 39 (11):1547-56.

The RPD3L HDAC complex is essential for the heat stress response in yeast. Ruiz-Roig C, Viéitez C, Posas F and de Nadal E. Mol Microbiol. 2010 May;76(4):1049-62 

Whole genome analysis of p38 SAPK-mediated gene expression upon stress. Ferreiro I, Joaquin M, Islam A, Gomez-Lopez G, Barragan M, Lombardía L, Domínguez O, Pisano DG, Lopez-Bigas N, Nebreda AR and Posas F. BMC Genomics 2010 11:144

Multilayered control of gene expression by stress-activated protein kinases. de Nadal E and Posas F. EMBO J. 2010 29 (1):4-13

Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisae. Klopf E, Paskova L, Solé C, Mas G, Petryshyn A, Posas F, Wintersberger U, Ammerer G, Schüller C. Mol Cell Biol. 2009 Sep;29(18):4994-5007

The Stress-activated Protein Kinase Hog1 Mediates S-phase Delay in Response to Osmostress. Yaakov G, Duch A, García-Rubio M, Clotet J, Jimenez J, Aguilera A and Posas F. Mol Biol Cell. 29 (18):4994-5007 (2009)

Dynamic Signaling in The Hog1 MAPK Pathway Relies on High Basal Signal. Macia J, Regot S, Peeters T, Conde N, Solé R  and Posas F. Transduction. Science Signaling 2 (63):1-9 (2009)

Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes. Mas G, de Nadal E, Dechant R, Rodríguez de la Concepción ML, Logie C, Jimeno-González S, Chávez S, Ammerer G and Posas F. EMBO J. 28 (4):326-336 (2009)


Mucins, osmosensors in eukaryotic cells? de Nadal E, Real FX and Posas F. Trends Cell Biol 17: 571-574 (2007).

Control of cell cycle in response to osmostress: lessons from yeast. Clotet J and Posas F. Methods Enzymol. 428: 63-76 (2007).

Selective requirement for SAGA in HOG1-mediated gene expression depending on the severity of the external osmostress conditions. Zapater M, Sohrmann M, Peter M, Posas F and de Nadal E. Mol. Cell. Biol. 27(11): 3900-3910 (2007).

The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress. Proft M, Mas G, de Nadal E, Vendrell A, Noriega N, Struhl K and Posas F. Molecular Cell. 23: 241-250 (2006). 

Phosphorylation of Hsl1 by Hog1 leads to a G(2) arrest essential for cell survival at high osmolarity.  Clotet J, Escoté X , Adrover MA, Yaakov G, Gari E, Aldea M, de Nadal E and Posas F. EMBO J. 25 (11):2338-46 (2006).  

Control of cell cycle progression by the stress-activated Hog1 MAPK. Zapater M, Clotet J, Escoté X and Posas F. Cell Cycle. 2005 Jan; 4(1):6-7.


Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1. Escoté X, Zapater M, Clotet J and Posas F. Nat. Cell. Biol. 6 (10): 997-1002 (2004). 

Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways. Tomás-Cobos L, Casadomé L, Mas G, Sanz P and Posas F. J Biol Chem. 2004 May 21; 279(21):22010-9.

The Hog1 MAP kinase recruits the Rpd3 histone deacetylase to activate osmoresponsive genes. de Nadal E, Zapater M, Alepuz PM, Sumoy L, Mas G and Posas F. Nature 427 (6972): 370-374 (2004)

Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II. Alepuz PM, De Nadal E, Zapater M, Ammerer G and Posas F. EMBO J. 22: 2433-2442 (2003).

Targeting the MEF2-Like Transcription Factor Smp1 by the Stress-Activated Hog1 Mitogen-Activated Protein Kinase. de Nadal E, Casadomé L and Posas F. Mol. Cell. Biol. 23: 229-37 (2003). 

Dealing with osmostress through MAP Kinase activation. de Nadal E, Alepuz PM and Posas F. EMBO Rep. 3: 735-740 (2002). 

Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress. Proft M, Pascual-Ahuir A, de Nadal E, Ariño J, Serrano R and Posas F. EMBO J. 20: 1123-1133 (2001).